Coronavirus Updates

So, What’s the Big Deal?

I have heard this question for weeks now due to the disruption of our daily lives by the intrusion of the Coronavirus Pandemic. As of April 6, the infected/deaths in the USA from the flu was 54,430,000/63,000 and the Coronavirus 370,397/11,042. Many, understandably, want to know why are so many are worried about Coronavirus if the number is small compared to the Flu. Let’s try to clarify.

Each infectious entity differs by its virulence, that is the ability to get you sick. Some are strong and others not. Tuberculosis and HIV are not very strong, so you need a large amount of “bugs” (or inoculum) to get you sick. The Bubonic Plague is the strongest known. Just one Yersinia pestis bacillum is needed to get a person sick. To put it into perspective, Coronavirus is almost 10 times stronger than the flu. It is very contagious.

The flu has an incubation period of 3-5 days and Coronavirus 5-14 days. Incubation is from when you come in contact (become infected) with the virus till the time you get sick. For each virus, a person may start shedding the virus and infecting others about 12 hours after first coming in contact the virus. However, after about a day, the person with the flu is out of circulation because he or she is sick. The person infected with Coronavirus may continue to spread the virus for another 12 days. So, it has a long incubation period. This is dangerous.

Viruses are very small organisms that contain tiny amounts of genetic material either DNA or RNA. This material is attached to protective protein material and both together are called a nucleocapsid. This is surrounded by a shell called the membrane which protects the nucleocapsid. Sticking out of the membrane are spikes that the virus uses to attach to a cell in our body. Coronavirus spikes have a high affinity for something called ACE-2 receptors in our body. We have a very high amount of these receptors in our lungs, hence pneumonia. Antiviral medications typically are designed to attack one of these structures.  


Once the virus attaches to the cell, the membranes fuse together with the cell membrane and the nucleocapsid enters the cell and the viral genetic material takes over at some point.

We have two different immune systems: innate and acquired or adaptive immune system. The latter system is the one responsible for the production of antibodies. In terms of evolution, this is a very effective and stunning system, but very slow. It takes about 3 weeks to start to produce antibodies (the key cofactor for antibodies to be effective is Vitamin C).  

If someone sneezes on you, you do not have 3 weeks. The other system is the innate system which is based on the shape or pattern of the “bug”. This is activated within 8-10 minutes from exposure. A key cofactor in critical resolution of the infection is Vitamin D. If you do not have enough Vit D, you cannot destroy the virus.

During these times, we believe that everyone should be supplementing with at least 5,000 IU/d of Vit D daily and 1,000 mg of Vit C. If, unfortunately, one becomes ill, you should increase that to 10,000 IU/d for 5 days, then down to 5,000 IU/d.

Clinically:  

  • 81% have mild or not symptoms at all
  • 14% are severe
  • 5% become critical and of these 7% die.

Clinical features: 

  • Fever 99%
  • Fatigue 70%
  • Dry cough 59%
  • Anorexia (loss of appetite)         40%
  • Myalgias (muscle aches)             35%
  • Dyspnea (shortness of breath)   31 %
  • Productive cough                          27 %

         *Less common are headache, sore throat and a runny nose.

Recovery is typically 2-6 weeks, depending on the age and health of the individual.

It has been shown that the drug Hydroxychloroquine blocks the Coronavirus spike apparatus so it cannot attach to the ACE-2 receptor of the cell. This was just approved by the FDA on March 19 for treatment. One study showed it reduced the sick time from 20 down to 6 days. Another drug is Camostat which stops the virus from entering the cell (by interfering with the fusion of membranes).

The only entry into our body is through the mouth, nose or eyes. So, cover up.

The virus can last hours and even days on dry surfaces and clothing. It is killed in 3 seconds with 60% alcohol. Hand sanitizers are excellent. When washing hands, one needs to wash for 20 seconds.

If we do what the President and the Coronavirus task force suggest, this can be over soon. If there is strict isolation, this is all over in 2-3 weeks. The problem is, not everyone is listening. Of theoretical concern, is the fact that two of the antibodies that our body makes against the Coronavirus can cross react with our myelin. This is the protective insulation layer around our nerves. Antibodies against myelin are a cause of multiple sclerosis. This has been the subject of current clinical research.

Of note, the Coronavirus is the fourth pathogen to escape from the Wuhan research facility in China. A previous problem was SARS (2002).

Preventive actions and nutrition

Avoid dry air environment and drink a lot of water (2 Liters/d). Dry mucus membranes become thin and fragile and can allow millions of viruses (large inoculum) to invade your body and overwhelm the immune system. It is much easier to defend against viruses with a moist, thick respiratory mucus membrane.

Good nutrition with an anti-inflammatory dietary regimen: fresh fruit and vegetables. Steamed or boiled fowl or meat. Avoid all sweets and unsprouted grains.

Take also:

  • High dose multivitamin and mineral supplement
  • Vitamin A, at least 25,000 IU/Day
  • Vitamin D, 5,000 IU/D (blood level 80-100)
  • Vitamin C 1-2 grams/Day

Get good sleep.

Advanced Information

The system we use to bring air from the outside to the inside is the respiratory system. At the end of the respiratory system are the air sacs, or alveoli. By the time the air reaches the alveoli it is near or at body temperature. The lining of the system is called mucus membranes. The mouth leads to the oropharynx which is eventually divided into the “food pipe” (esophagus) and “wind pipe” (trachea). The trachea subdivides into bronchioles which get narrower and narrower till it ends in the alveoli. The mucus membranes in the bronchi secrete water, mucus, secretory antibodies and other substances that help resist infection. In addition, the nasal and paranasal sinuses haveNO (nitric oxide) which helps prevent infection. The mucus membranes contain a large number of white blood cells called macrophages. These are big cells gobble up debris (from pollution, dust cigarette smoke…) and infectious elements ( bacteria, viruses…). Once inside the macrophage, small bubble like structures that resemble selzer bubbles, collect and form a big bubble around the infectious entity. The bubbles are called lysosomes and contain some of the post powerful digestive enzymes known on the planet. These enzymes can pretty much digest any organic material. These enzymes must be activated to execute digestion, and a key cofactor is Vit D. If you do not have enough Vitamin D, you cannot effectively digest the “bug”.

The hairs in the nostrils strain most of the large particles in the air and prevent them from getting to the deep recesses of the lungs. Particles, including viruses, that do get by, typically get stuck in the mucus of the membranes and are trapped. (The bronchiole system is a twisting system of “pipes” so the particles typically will hit the wall when traveling inside). The particles that get past the tonsils and adenoids (large collections of lymph tissue to destroy “bugs”) get stuck in the mucus and are moved upwards towards the adenoids for destruction, or to be coughed up. The movement upwards is done by small hairs called cilia.  These little hairs that beat in a coordinated fashion at a frequency of ~1,500 cycles per minute and are capable of moving particles away from the lungs at a rate of at least 16 mm/min! Any particle that reaches the alveoli are ingested by the macrophages.

If this elaborate system breaks down, infectious disease is likely.

To reduce the risk of getting sick from bacteria or viruses there are several things we can do, some previously stated.

  • Avoid dry air. Use a humidifier if needed, and drink a lot of water. Dry fragile mucus membranes can crack and breach the defenses to allow viruses in.
  • Do no smoke cigarettes. The smoke inactivates the cilia so particles are not moved away from the inner lung.
  • Good nutrition with an anti-inflammatory dietary regimen: fresh fruit and vegetables. An anti-inflammatory diet increases the Nitric Oxide, which is needed to fight infection.
  • Steamed or boiled fowl or meat. Avoid all sweets and unsprouted grains. Sweets, and high glycemic grains, increase your insulin which is ok, unless it is too elevated and then it can be very detrimental for your immune system.
  • Get good sleep.

 

Take also:

  • High dose multivitamin and mineral supplement
  • Vitamin A, at least 25,000 IU/Day
  • Vitamin D, 5,000 IU/D (blood level 80-100)
  • Vitamin C 1-2 grams/Day
  •  L-Arginine, 2-6 grams a day. (Increases your Nitric Oxide)

 

Please be sure to take the “good” supplements and vitamins. Many of the “good brands” will state that their products have been independently validated for purity and quality. Make sure you read that, otherwise consider avoiding it. As we all have learned recently, 90% of all prescription drugs and 95% of over the counter supplements and vitamins ALL are made in China. The FDA recently stated that so much medicines and supplements are coming into the country from China that they cannot keep up with checking the products.

Not very reassuring.

 

Interesting Data from WHO:

Deaths in the entire World January 1 –April 5, 2020

 

Coronavirus      

69,424

Influenza           

127,645

Malaria              

257,502

Suicide              

281,514

Motor Vehicle Accidents 

354,377

HIV                         

441,312

Alcohol related        

556,593

Cigarette Smoking   

1,312,000

Cancer                       

2,156,055

Starvation                 

2,982,000

Abortion                    

11,158,565

 

Synopsis Coronavirus 2020 (COVID-19)

The virus is 10 times more contagious than the flu. Very long incubation time, up to 14 days (the reason for 14 days of isolation after exposure)
Enters the body through respiratory tract. Only entry points are: mouth, both nostrils and both eyes. Masks reduce spread to other people.

The virus gains access to the respiratory system and needs to attach to the ACE-2 receptor, and then enters the cell.
Hydroxychloroquine has been shown to block the attachment to the ACE-2 receptor thereby stopping the virus entry into the cell. Camostat inhibits the virus from entering the cell.

Once in the cell, some people (2.5% of the population) have an exaggerated inflammatory response, which is detrimental to our lungs. Sort of like some people after surgery develop a big scar (keloid) and others do not. Most deaths appear to be due to this exaggerated inflammatory response. Some drugs (Sarilumab, Siltumimab and Tocilizumab) are special IL-6 inhibitors and may stop this response.

We fully agree with the President, maintain social distancing. Stay isolated and go out only when need to.

Any questions please call us.

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